Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients
نویسندگان
چکیده
منابع مشابه
A Stochastic Model for the Normal Tissue Complication Probability (NTCP) in Radiation Treatment of Cancer
The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth death process to define an organ specific and patient specific NTCP. We emphasise an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework allows for a direct ...
متن کاملA stochastic model for the normal tissue complication probability (NTCP) and applicationss.
The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth-death process to define an organ-specific and patient-specific NTCP. We emphasize an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework is based on simple m...
متن کاملA prospective cohort study on radiation-induced hypothyroidism: development of an NTCP model.
PURPOSE To establish a multivariate normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism. METHODS AND MATERIALS The thyroid-stimulating hormone (TSH) level of 105 patients treated with (chemo-) radiation therapy for head-and-neck cancer was prospectively measured during a median follow-up of 2.5 years. Hypothyroidism was defined as elevated serum TSH with d...
متن کاملAssessing the uncertainty in a normal tissue complication probability difference (∆NTCP): radiation-induced liver disease (RILD) in liver tumour patients treated with proton vs X-ray therapy
Modern radiotherapy technologies such as proton beam therapy (PBT) permit dose escalation to the tumour and minimize unnecessary doses to normal tissues. To achieve appropriate patient selection for PBT, a normal tissue complication probability (NTCP) model can be applied to estimate the risk of treatment-related toxicity relative to X-ray therapy (XRT). A methodology for estimating the differe...
متن کاملNormal tissue complication probability (NTCP) parameters for breast fibrosis: pooled results from two randomised trials.
INTRODUCTION The dose-volume effect of radiation therapy on breast tissue is poorly understood. We estimate NTCP parameters for breast fibrosis after external beam radiotherapy. MATERIALS AND METHODS We pooled individual patient data of 5856 patients from 2 trials including whole breast irradiation followed with or without a boost. A two-compartment dose volume histogram model was used with b...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2018
ISSN: 1471-2407
DOI: 10.1186/s12885-018-4348-z